Sister to Sister is a one on one evidence based intervention (EBI) that targets HIV negative women with the knowledge, belief, motivation, confidence and skills necessary to help them make behavioural changes that will reduce their risks of STI/HIV infection. The intervention is highly structured and implemented in a primary health care setting by nurses, health educators, or other professional clinic staff using an implementation manual.

In SWOP-Kenya, the intervention has been tailored to attain optimal uptake among the female sex workers and adolescent and young women. A HIV negative female Peer Educator is trained through the sister to sister curriculum to enable peer to peer delivery of the intervention.